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Sertraline hydrochloride
Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
Catalog No. T0482Cas No. 79559-97-0
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Purity:99.86%
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Sertraline hydrochloride
Catalog No. T0482Alias Sertraline HCl, CP-51974-1 HClCas No. 79559-97-0
Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $47 | In Stock | |
| 10 mg | $57 | In Stock | |
| 25 mg | $105 | In Stock | |
| 50 mg | $189 | In Stock | |
| 100 mg | $247 | In Stock | |
| 200 mg | $321 | In Stock | |
| 500 mg | $542 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression. |
| Targets&IC50 | 5-HT:13 nM(Ki) |
| In vitro | Sertraline HCl significantly enhances locomotor activity in mice during the antidepressant Porsolt forced swim test. Intraperitoneal injection of 32 μMol/kg Sertraline HCl inhibits more than 50% of 5-hydroxytryptamine uptake by rat striatal synaptosomes. Sertraline HCl reverses 5-hydroxytryptamine depletion caused by PCA, proving to be six times more effective than chlorpromazine and sixty times more effective than amitriptyline. Acute repetitive administration of Sertraline reduces the serotonin content in whole blood. Chronic administration of Sertraline HCl in rats decreases the binding of [3H] dihydroalprenolol to cortical membranes and the cyclic AMP response to norepinephrine in the limbic forebrain adenylate cyclase. |
| In vivo | Sertraline is more effective than fluvoxamine, zimelidine, norzimelidine, fluoxetine, or clomipramine in preferentially inhibiting the uptake of 5-HT (serotonin), with comparatively weaker inhibition of NE (norepinephrine) absorption. However, sertraline exhibits lower selectivity than these agents in blocking the uptake of 5-HT relative to DA (dopamine). |
| Alias | Sertraline HCl, CP-51974-1 HCl |
| Molecular Weight | 342.691 |
| Formula | C17H18Cl3N |
| Cas No. | 79559-97-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (175.08 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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